hrp0097fc14.1 | Late Breaking | ESPE2023

Sleep health characteristics in children with congenital adrenal hyperplasia

Golob Laura , Liu Wenxi , Mercado-Munoz Yesica , Singh Anvita , Hodges James , Siegel Lianne , Morero Helena , Gao Zan , Simon Stacey , Sarafoglou Kyriakie

Introduction: Cortisol secretion is circadian-driven and plays a significant role in sleep quality. In children with congenital adrenal hyperplasia (CAH) hydrocortisone is the preferred treatment. Hydrocortisone has a short half-life producing alternating hyper- and hypocortisolemia, a non-physiologic cortisol profile, likely disrupting sleep. However, minimal literature exists on sleep health in children with CAH.Objective:</str...